Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions.

doi:10.1016/j.arr.2016.03.002

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Article

Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions.

Ageing research reviews - 1 Jan 2017

Oshima Junko, Sidorova Julia M, Monnat Raymond J

Abstract excerpt

Werner syndrome (WS) is a prototypical segmental progeroid syndrome characterized by multiple features consistent with accelerated aging. It is caused by null mutations of the WRN gene, which encodes a member of the RECQ family of DNA helicases. A unique feature of the WRN helicase is the presence of an exonuclease domain in its N-terminal region. Biochemical and cell biological studies during the past decade...

Topics

Aging, Premature
DNA Repair
DNA Replication
Exodeoxyribonucleases
Humans
Mutation
Werner Syndrome
Werner Syndrome Helicase

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Identifiers

PMID: 26993153
DOI: 10.1016/j.arr.2016.03.002
PMCID: PMC5025328

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