Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

WRN mutations in Werner syndrome.

Human mutation - 1 Jan 1999

Moser M J, Oshima J, Monnat R J

Abstract excerpt

Werner syndrome (WS) is one of a group of human genetic diseases that have recently been linked to deficits in cellular helicase function. We review the spectrum of WS-associated WRN mutations, the organization and potential functions of the WRN protein, and potential mechanistic links between the loss of WRN function and pathogenesis of the WS clinical and cellular phenotypes.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 8
Share to DNA Helicases
Share to Exodeoxyribonucleases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Nuclear Localization Signals

Share to Protein Processing, Post-Translational

Share to RecQ Helicases

Share to Werner Syndrome

Share to Werner Syndrome Helicase

Source

Identifiers

PMID: 10220139
DOI: 10.1002/(SICI)1098-1004(1999)13:4<271::AID-HUMU2>3.0.CO;2-Q

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

WRN mutations in Werner syndrome.PMID 10220139Read ↗

Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome ProteinSemantic proximity Read ↗

Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group.Semantic proximity Read ↗

Werner Syndrome, aging and cancer.Semantic proximity Read ↗

WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects.Semantic proximity Read ↗

Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases.Semantic proximity Read ↗

Genetic and epigenetic insights into Werner SyndromeSemantic proximity Read ↗

Research on Werner Syndrome: Trends from Past to Present and Future ProspectsSemantic proximity Read ↗

The Werner syndrome RECQ helicase as a therapeutic target: new insights.Semantic proximity Read ↗

Werner syndrome protein: functions in the response to DNA damage and replication stress in S-phase.Semantic proximity Read ↗

The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis.Semantic proximity Read ↗

A novel mutation of the WRN gene in a Chinese patient with Werner syndrome.Semantic proximity Read ↗

Werner syndrome and mutations of the WRN and LMNA genes in France.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.