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Article

Werner syndrome protein contains three structure-specific DNA binding domains.

The Journal of biological chemistry - 26 Dec 2003

von Kobbe Cayetano, Thomä Nicolas H, Czyzewski Bryan K, Pavletich Nikola P, Bohr Vilhelm A

Abstract excerpt

Werner syndrome (WS) is a premature aging syndrome caused by mutations in the WS gene (WRN) and a deficiency in the function of the Werner protein (WRN). WRN is a multifunctional nuclear protein that catalyzes three DNA-dependent reactions: a 3'-5'-exonuclease, an ATPase, and a 3'-5'-helicase. De...

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Identifiers

PMID: 14534320
DOI: 10.1074/jbc.M308338200

Genes

WRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14534320-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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