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Article

Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity.

Aging cell - 1 Jun 2008

Saunders Robert D C, Boubriak Ivan, Clancy David J, Cox Lynne S

Abstract excerpt

The premature human aging Werner syndrome (WS) is caused by mutation of the RecQ-family WRN helicase, which is unique in possessing also 3'-5' exonuclease activity. WS patients show significant genomic instability with elevated cancer incidence. WRN is implicated in restraining illegitimate recombination, especially during DNA replication. Here we identify a Drosophila ortholog of the WRN exonuclease encoded by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18346216
DOI: 10.1111/j.1474-9726.2008.00388.x
PMCID: PMC2408639

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity.PMID 18346216Read ↗

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