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Article

Werner Protein Protects Nonproliferating Cells from Oxidative DNA Damage

15 Nov 2005

Abstract excerpt

Werner syndrome, caused by mutations of the WRN gene, mimics many changes of normal aging. Although roles for WRN protein in DNA replication, recombination, and telomere maintenance have been suggested, the pathology of rapidly dividing cells is not a feature of Werner syndrome. To identify cellular events that are specifically vulnerable to WRN deficiency, we used RNA interference (RNAi) to knockdown WRN or BLM...

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PMID: 16287861
DOI: 10.1128/mcb.25.23.10492-10506.2005

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