Article
Genetic analysis of a mouse cross implicates an anti-inflammatory gene in control of atherosclerosis susceptibility.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2017
Garrett Norman E, Grainger Andrew T, Li Jing, Chen Mei-Hua, Shi Weibin
Abstract excerpt
Nearly all genetic crosses generated from Apoe-/- or Lldlr-/- mice for genetic analysis of atherosclerosis have used C57BL/6 J (B6) mice as one parental strain, thus limiting their mapping power and coverage of allelic diversity. SM/J-Apoe -/- and BALB/cJ-Apoe -/- mice differ significantly in atherosclerosis susceptibility. 224 male F2 mice were generated from the two Apoe -/- strains to perform quantitative...
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