Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling.

Molecular and cellular biology - 1 Jan 2006

Kim Keun Il, Yan Ming, Malakhova Oxana, Luo Jiann-Kae, Shen Mei-Feng, Zou Weiguo, de la Torre Juan Carlos, Zhang Dong-Er

Abstract excerpt

The expression of ubiquitin-like modifier ISG15 and its conjugation to target proteins are highly induced by interferon (IFN) stimulation and during viral and bacterial infections. However, the biological significance of this modification has not been clearly understood. To investigate the function of protein modification by ISG15, we generated a mouse model deficient in UBE1L, an ISG15-activating enzyme....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ubiquitin Thiolesterase
Share to Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-beta

Share to Lymphocytic choriomeningitis virus

Share to Rhabdoviridae Infections

Share to Ubiquitin-Activating Enzymes

Share to Ubiquitins

Share to Vesicular stomatitis Indiana virus

Source

Open in PubMed Open full text

Identifiers

PMID: 16382139
DOI: 10.1128/MCB.26.2.472-479.2006
PMCID: PMC1346917

Genes

ISG15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling.PMID 16382139Read ↗

Reexamination of the role of ubiquitin-like modifier ISG15 in the phenotype of UBP43-deficient mice.Semantic proximity Read ↗

The diverse repertoire of ISG15: more intricate than initially thoughtSemantic proximity Read ↗

Novel Mode of ISG15-Mediated Protection against Influenza A Virus and Sendai Virus in MiceSemantic proximity Read ↗

ISG15 and ISGylation in Human DiseasesSemantic proximity Read ↗

The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase.Semantic proximity Read ↗

ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A ReviewSemantic proximity Read ↗

ISG15 driven cellular responses to virus infectionSemantic proximity Read ↗

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation.Semantic proximity Read ↗

Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus RegulatorsSemantic proximity Read ↗

IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis virusesSemantic proximity Read ↗

ISG-15, beyond its functions in the cell: a mini reviewSemantic proximity Read ↗

Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.