Article
Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation.
Nature - 1 Jan 2015
Zhang Xianqin, Bogunovic Dusan, Payelle-Brogard Béatrice, Francois-Newton Véronique, Speer Scott D, Yuan Chao, Volpi Stefano, Li Zhi, Sanal Ozden, Mansouri Davood, Tezcan Ilhan, Rice Gillian I, Chen Chunyuan, Mansouri Nahal, Mahdaviani Seyed Alireza, Itan Yuval, Boisson Bertrand, Okada Satoshi, Zeng Lu, Wang Xing, Jiang Hui, Liu Wenqiang, Han Tiantian, Liu Delin, Ma Tao, Wang Bo, Liu Mugen, Liu Jing-Yu, Wang Qing K, Yalnizoglu Dilek, Radoshevich Lilliana, Uzé Gilles, Gros Philippe, Rozenberg Flore, Zhang Shen-Ying, Jouanguy Emmanuelle, Bustamante Jacinta, García-Sastre Adolfo, Abel Laurent, Lebon Pierre, Notarangelo Luigi D, Crow Yanick J, Boisson-Dupuis Stéphanie, Casanova Jean-Laurent, Pellegrini Sandra
Abstract excerpt
Intracellular ISG15 is an interferon (IFN)-α/β-inducible ubiquitin-like modifier which can covalently bind other proteins in a process called ISGylation; it is an effector of IFN-α/β-dependent antiviral immunity in mice. We previously published a study describing humans with inherited ISG15 deficiency but without unusually severe viral diseases. We showed that these patients were prone to mycobacterial disease...
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