Article
Reexamination of the role of ubiquitin-like modifier ISG15 in the phenotype of UBP43-deficient mice.
Molecular and cellular biology - 1 Dec 2005
Knobeloch Klaus-Peter, Utermöhlen Olaf, Kisser Agnes, Prinz Marco, Horak Ivan
Abstract excerpt
UBP43/USP18 was described as a specific protease that removes conjugated ubiquitin-like modifier ISG15 from target proteins. The severe phenotype of UBP43(-/-) mice characterized by premature death, brain cell injury, and deregulated STAT1 signaling was ascribed to an enhanced conjugation of ISG15. In contrast, no phenotypic changes were detected in ISG15(-/-) mice. To verify the role of ISG15 in the phenotype of...
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