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Article

Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection.

Journal of virology - 1 Jan 2009

Lai Caroline, Struckhoff Jessica J, Schneider Jana, Martinez-Sobrido Luis, Wolff Thorsten, García-Sastre Adolfo, Zhang Dong-Er, Lenschow Deborah J

Abstract excerpt

ISG15 functions as a critical antiviral molecule against influenza virus, with infection inducing both the conjugation of ISG15 to target proteins and production of free ISG15. Here, we report that mice lacking the ISG15 E1 enzyme UbE1L fail to form ISG15 conjugates. Both UbE1L(-/-) and ISG15(-/-...

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Source

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Identifiers

PMID: 19004958
DOI: 10.1128/JVI.00105-08
PMCID: PMC2612374

Genes

ISG15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19004958-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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