Article
The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase.
The Journal of biological chemistry - 5 Nov 2004
Tokarz Sara, Berset Catherine, La Rue Janna, Friedman Kevin, Nakayama Kei-Ichi, Nakayama Keiko, Zhang Dong-Er, Lanker Stefan
Abstract excerpt
The Skp2 oncoprotein belongs to the family of F-box proteins that function as substrate recognition factors for SCF (Skp1, cullin, F-box protein) E3 ubiquitin-ligase complexes. Binding of the substrate to the SCFSkp2 complex catalyzes the conjugation of ubiquitin molecules to the bound substrate, resulting in multi-ubiquitination and rapid degradation by the 26 S proteasome. Using Skp2 as bait in a yeast...
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