Article
Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition.
Journal of virology - 1 Mar 2004
Das Atze T, Brummelkamp Thijn R, Westerhout Ellen M, Vink Monique, Madiredjo Mandy, Bernards René, Berkhout Ben
Abstract excerpt
Short-term assays have suggested that RNA interference (RNAi) may be a powerful new method for intracellular immunization against human immunodeficiency virus type 1 (HIV-1) infection. However, RNAi has not yet been shown to protect cells against HIV-1 in long-term virus replication assays. We stably introduced vectors expressing small interfering RNAs (siRNAs) directed against the HIV-1 genome into human T cells...
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