Article
Induction and inhibition of ciprofloxacin resistance-conferring mutations in hypermutator bacteria.
Antimicrobial agents and chemotherapy - 1 Jan 2006
Cirz Ryan T, Romesberg Floyd E
Abstract excerpt
The emergence of drug-resistant bacteria poses a serious threat to human health. Bacteria often acquire resistance from a mutation of chromosomal genes during therapy. We have recently shown that the evolution of resistance to ciprofloxacin in vivo and in vitro requires the induction of a mutation that is mediated by the cleavage of the SOS repressor LexA and the associated derepression of three specialized DNA...
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