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Article

Response of Escherichia coli hypermutators to selection pressure with antimicrobial agents from different classes.

The Journal of antimicrobial chemotherapy - 1 Jun 2002

Miller Keith, O'Neill Alexander John, Chopra Ian

Abstract excerpt

The responses of hypermutable Escherichia coli strains to selection with antibiotics having different endogenous resistance potentials were determined. Selections with rifampicin or ciprofloxacin at 4 x MIC, i.e. conditions where they act as single target agents against RpoB and GyrA, respectively, demonstrated that some hypermutators generated resistant mutants with frequencies up to 1000-fold higher than normal...

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Source

Identifiers

PMID: 12039884
DOI: 10.1093/jac/dkf044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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