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Article

Effect of ciprofloxacin concentration on the frequency and nature of resistant mutants selected from Pseudomonas aeruginosa mutS and mutT hypermutators.

Antimicrobial agents and chemotherapy - 1 Aug 2011

Morero Natalia R, Monti Mariela R, Argaraña Carlos E

Abstract excerpt

The rapid emergence of drug resistance upon treatment of Pseudomonas aeruginosa infections with fluoroquinolones is a serious concern. In this study, we report the effect of hypermutability on the mutant selection window for ciprofloxacin (CIP) by comparing the hypermutator MPAO1 mutS and mutT strains with the wild-type strain. The mutant selection window was shifted to higher CIP concentrations for both...

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Identifiers

PMID: 21646492
DOI: 10.1128/AAC.01826-10
PMCID: PMC3147628

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