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Article

Spontaneous mutation at a 5-methylcytosine hotspot is prevented by very short patch (VSP) mismatch repair.

Genetics - 1 May 1991

Lieb M

Abstract excerpt

In many strains of Escherichia coli, the product of gene dcm methylates the internal cytosines in the sequence 5'CC(A or T)GG. Spontaneous deamination of 5-methylcytosine produces thymine which, if not corrected, can result in a transition mutation. 5-Methylcytosines in the lacI gene are hotspots for spontaneous C to T mutations. dcm is linked to vsr, a gene required for very short patch (VSP) repair. VSP repair...

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Identifiers

PMID: 1829427
DOI: 10.1093/genetics/128.1.23
PMCID: PMC1204449

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Spontaneous mutation at a 5-methylcytosine hotspot is prevented by very short patch (VSP) mismatch repair.PMID 1829427Read ↗

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