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Article

Amplification of Hot DNA segments in Escherichia coli.

Molecular microbiology - 1 Sept 2002

Kodama Ken-Ichi, Kobayashi Takehiko, Niki Hironori, Hiraga Sota, Oshima Taku, Mori Hirotada, Horiuchi Takashi

Abstract excerpt

In Escherichia coli, a replication fork blocking event at a DNA replication terminus (Ter) enhances homologous recombination at the nearby sister chromosomal region, converting the region into a recombination hotspot, Hot, site. Using a RNaseH negative (rnhA-) mutant, we identified eight kinds of Hot DNAs (HotA-H). Among these, enhanced recombination of three kinds of Hot DNAs (HotA-C) was dependent on fork...

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Share to Chromosomes, Bacterial
Share to DNA, Circular
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Electrophoresis, Gel, Pulsed-Field

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Share to Ribonuclease H

Share to Terminator Regions, Genetic

Share to Transformation, Bacterial

Source

Identifiers

PMID: 12354226
DOI: 10.1046/j.1365-2958.2002.03141.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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