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TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to <i>Mycobacterium tuberculosis</i>

19 Dec 2005

Abstract excerpt

To investigate the role of Toll-like receptor (TLR)9 in the immune response to mycobacteria as well as its cooperation with TLR2, a receptor known to be triggered by several major mycobacterial ligands, we analyzed the resistance of TLR9(-/-) as well as TLR2/9 double knockout mice to aerosol infection with Mycobacterium tuberculosis. Infected TLR9(-/-) but not TLR2(-/-) mice displayed defective...

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PMID: 16365150
DOI: 10.1084/jem.20051782

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