Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TLR9-dependent activation of dendritic cells by DNA from Leishmania major favors Th1 cell development and the resolution of lesions.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2009

Abou Fakher Faihaa Hkima, Rachinel Nicolas, Klimczak Martine, Louis Jacques, Doyen Noëlle

Abstract excerpt

In its vertebrate host, Leishmania encounters cells that express TLRs. Using genetically resistant C57BL/6 mice deficient in either TLR2, 4, or 9, we show in this study that only TLR9-deficient mice are more susceptible to infection with Leishmania major. TLR9-deficient mice resolved their lesion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Protozoan
Share to Dendritic Cells
Share to DNA, Protozoan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunophenotyping

Share to Leishmania major

Share to Leishmaniasis, Cutaneous

Share to Th1 Cells

Share to Toll-Like Receptor 9

Source

Identifiers

PMID: 19155485
DOI: 10.4049/jimmunol.182.3.1386

Genes

TLR9
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19155485-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TLR9-dependent activation of dendritic cells by DNA from Leishmania major favors Th1 cell development and the resolution of lesions.PMID 19155485Read ↗

TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Toll-like receptor 9 regulates the lung macrophage phenotype and host immunity in murine pneumonia caused by Legionella pneumophila.Semantic proximity Read ↗

TLR9 regulates the mycobacteria-elicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4.Semantic proximity Read ↗

NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs.Semantic proximity Read ↗

Infection of C57BL/10ScCr and C57BL/10ScNCr mice withLeishmania majorreveals a role for Toll-like receptor 4 in the control of parasite replicationSemantic proximity Read ↗

Protein–DNA Complex Is the Exclusive Malaria Parasite Component That Activates Dendritic Cells and Triggers Innate Immune ResponsesSemantic proximity Read ↗

Transmembrane mutations in Toll-like receptor 9 bypass the requirement for ectodomain proteolysis and induce fatal inflammation.Semantic proximity Read ↗

Distinct Responses of Lung and Spleen Dendritic Cells to the TLR9 Agonist CpG OligodeoxynucleotideSemantic proximity Read ↗

Recruitment and Endo-Lysosomal Activation of TLR9 in Dendritic Cells Infected with <i>Trypanosoma cruzi</i>Semantic proximity Read ↗

Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection.Semantic proximity Read ↗

Skin resident memory cells generated by the <i>L. major</i> centrin gene deleted parasites mediate protective immune response analogous to leishmanizationSemantic proximity Read ↗

DNA- Salmonella enterica Serovar Typhimurium Primer-Booster Vaccination Biases towards T Helper 1 Responses and Enhances Protection against Leishmania major Infection in MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.