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Article

The adaptor molecule CARD9 is essential for tuberculosis control.

The Journal of experimental medicine - 12 Apr 2010

Dorhoi Anca, Desel Christiane, Yeremeev Vladimir, Pradl Lydia, Brinkmann Volker, Mollenkopf Hans-Joachim, Hanke Karin, Gross Olaf, Ruland Jürgen, Kaufmann Stefan H E

Abstract excerpt

The cross talk between host and pathogen starts with recognition of bacterial signatures through pattern recognition receptors (PRRs), which mobilize downstream signaling cascades. We investigated the role of the cytosolic adaptor caspase recruitment domain family, member 9 (CARD9) in tuberculosis. This adaptor was critical for full activation of innate immunity by converging signals downstream of multiple PRRs....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 20351059
DOI: 10.1084/jem.20090067
PMCID: PMC2856020

Genes

CARD9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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