Myeloid Differentiation Primary Response Gene (88)– and Toll‐Like Receptor 2–Deficient Mice Are Susceptible to Infection with Aerosolized<i>Legionella pneumophila</i>

Abstract excerpt

BACKGROUND: Toll-like receptors (TLRs) are a family of proteins that orchestrate innate immune responses to microbes. Although pathogens are typically recognized by multiple TLRs, the specific roles of individual TLRs in mediating host protection during in vivo infection are not well understood. METHODS: We compared the roles of myeloid differentiation primary response gene (88) (MyD88), which regulates signaling...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Immune Response and Inflammation
• Share to Legionella and Acanthamoeba research
• Share to Pneumonia and Respiratory Infections