Article
Toll-like receptor 9 regulates the lung macrophage phenotype and host immunity in murine pneumonia caused by Legionella pneumophila.
Infection and immunity - 1 Jul 2008
Bhan Urvashi, Trujillo Glenda, Lyn-Kew Kenneth, Newstead Michael W, Zeng Xianying, Hogaboam Cory M, Krieg Arthur M, Standiford Theodore J
Abstract excerpt
Experiments were performed to determine the contribution of TLR9 to the generation of protective immunity against the intracellular respiratory bacterial pathogen Legionella pneumophila. In initial studies, we found that the intratracheal (i.t.) administration of L. pneumophila to mice deficient in TLR9 (TLR9(-/-)) resulted in significantly increased mortality, which was associated with an approximately 10-fold...
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