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Article

Important Role for Toll-Like Receptor 9 in Host Defense against Meningococcal Sepsis

16 Sept 2008

Abstract excerpt

Neisseria meningitidis is a leading cause of meningitis and sepsis. The pathogenesis of meningococcal disease is determined by both bacterial virulence factors and the host inflammatory response. Toll-like receptors (TLRs) are prominent activators of the inflammatory response, and TLR2, -4, and -9 have been reported to be involved in the host response to N. meningitidis. While TLR4 has been suggested to play an...

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PMID: 18794294
DOI: 10.1128/iai.00615-08

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