Article
TLR2 regulates neutrophil recruitment and cytokine production with minor contributions from TLR9 during hypersensitivity pneumonitis.
PloS one - 1 Jan 2013
Andrews Kelly, Abdelsamed Hossam, Yi Ae-Kyung, Miller Mark A, Fitzpatrick Elizabeth A
Abstract excerpt
Hypersensitivity pneumonitis (HP) is an interstitial lung disease that develops following repeated exposure to environmental antigens. The disease results in alveolitis, granuloma formation and may progress to a fibrotic chronic form, which is associated with significant morbidity and mortality. The severity of the disease correlates with a neutrophil rich influx and an IL-17 response. We used the...
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