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Article

Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection.

Cellular microbiology - 1 Mar 2007

Albiger Barbara, Dahlberg Sofia, Sandgren Andreas, Wartha Florian, Beiter Katharina, Katsuragi Hiroaki, Akira Shizuo, Normark Staffan, Henriques-Normark Birgitta

Abstract excerpt

Toll-like receptor 9 (TLR9) induces an inflammatory response by recognition of unmethylated CpG dinucleotides, mainly present in prokaryotic DNA. So far, TLR9-deficient mice have been shown to be more sensitive than wild-type mice to viral, but not to bacterial infections. Here, we show that mice deficient in TLR9 but not in TLR1, TLR2, TLR4 and TLR6 or IL-1R/IL-18R are more susceptible to a respiratory tract...

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Source

Identifiers

PMID: 17004992
DOI: 10.1111/j.1462-5822.2006.00814.x

Genes

TLR9
TLR1
TLR2
TLR4
TLR6

Provenance

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