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Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic <i>Mycobacterium tuberculosis</i> infection but not acute infection with multiple intracellular pathogens

2022-12-29

Abstract excerpt

Macrophages employ an array of pattern recognition receptors to detect and eliminate intracellular pathogens that access the cytosol. The cytosolic carbohydrate sensors Galectin-3, -8, and -9 (Gal-3, Gal-8, and Gal-9) recognize damaged pathogen-containing phagosomes, and Gal-3 and Gal-8 are reported to restrict bacterial growth via autophagy in cultured cells. However, the contribution of these galectins to host r...

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Literature Corpus work
727e00b8-3642-5ff3-a3ab-0f8e229b6100
DOI
10.1101/2022.12.29.522180
Open publication

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Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic <i>Mycobacterium tuberculosis</i> infection but not acute infection with multiple intracellular pathogensDOI 10.1101/2022.12.29.522180
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