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Article

DNA sequence-specific recognition by a transcriptional regulator requires indirect readout of A-tracts.

Nucleic acids research - 1 Jan 2007

Mendieta Jesús, Pérez-Lago Laura, Salas Margarita, Camacho Ana

Abstract excerpt

The bacteriophage Ø29 transcriptional regulator p4 binds to promoters of different intrinsic activities. The p4-DNA complex contains two identical protomers that make similar interactions with the target sequence 5'-AACTTTTT-15 bp-AAAATGTT-3'. To define how the various elements in the target sequence contribute to p4's affinity, we studied p4 binding to a series of mutated binding sites. The binding specificity...

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Identifiers

PMID: 17452358
DOI: 10.1093/nar/gkm180
PMCID: PMC1904284

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Source receipt: pubmed, retrieved 7 Sept 2026.

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