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Article

Dual regulation of open-complex formation and promoter clearance by Arc explains a novel repressor to activator switch.

Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 1996

Smith T L, Sauer R T

Abstract excerpt

In studies of variants of the P(ant) promoter of bacteriophage P22, the Arc protein was found not only to slow the rate at which RNA polymerase forms open complexes but also to accelerate the rate at which the enzyme clears the promoter. These dual activities permit Arc, bound at a single operator subsite, to act as an activator or as a repressor of different promoter variants. For example, Arc activates a P(ant)...

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Topics

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Share to Escherichia coli
Share to Gene Expression Regulation, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Kinetics

Share to Promoter Regions, Genetic

Share to Repressor Proteins

Share to Transcription Factors

Share to Transcription, Genetic

Source

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Identifiers

PMID: 8799119
DOI: 10.1073/pnas.93.17.8868
PMCID: PMC38560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Dual regulation of open-complex formation and promoter clearance by Arc explains a novel repressor to activator switch.PMID 8799119Read ↗

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An aromatic residue switch in enhancer-dependent bacterial RNA polymerase controls transcription intermediate complex activity.Semantic proximity Read ↗

Role of an N(cap) residue in determining the stability and operator-binding affinity of Arc repressor.Semantic proximity Read ↗

Energy coupling between DNA binding and subunit association is responsible for the specificity of DNA-Arc interaction.Semantic proximity Read ↗

Mutations in β' subunit of Escherichia coli RNA polymerase perturb the activator polymerase functional interaction required for promoter clearance.Semantic proximity Read ↗

DNA sequence requirements for the activation of 434 P(RM) transcription by 434 repressor.Semantic proximity Read ↗

Stable DNA opening within open promoter complexes is mediated by the RNA polymerase beta'-jaw domain.Semantic proximity Read ↗

Dissection of two hallmarks of the open promoter complex by mutation in an RNA polymerase core subunit.Semantic proximity Read ↗

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P22 Arc repressor: enhanced expression of unstable mutants by addition of polar C-terminal sequences.Semantic proximity Read ↗

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