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Article

Extrinsic interactions dominate helical propensity in coupled binding and folding of the lactose repressor protein hinge helix.

Biochemistry - 9 May 2006

Zhan Hongli, Swint-Kruse Liskin, Matthews Kathleen Shive

Abstract excerpt

A significant number of eukaryotic regulatory proteins are predicted to have disordered regions. Many of these proteins bind DNA, which may serve as a template for protein folding. Similar behavior is seen in the prokaryotic LacI/GalR family of proteins that couple hinge-helix folding with DNA binding. These hinge regions form short alpha-helices when bound to DNA but appear to be disordered in other states. An...

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Identifiers

PMID: 16669632
DOI: 10.1021/bi052619p
PMCID: PMC2701349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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