Article
Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2005
Chang Shengjun, ran Ma Tian, Miranda R Dennis, Balestra Maureen E, Mahley Robert W, Huang Yadong
Abstract excerpt
Apolipoprotein (apo) E4, a 299-aa protein and a major risk factor for Alzheimer's disease, can be cleaved to generate C-terminal-truncated fragments that cause neurotoxicity in vitro and neurodegeneration and behavioral deficits in transgenic mice. To investigate this neurotoxicity, we expressed apoE4 with C- or N-terminal truncations or mutations in transfected Neuro-2a cells. ApoE4 (1-272) was neurotoxic, but...
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