Article

An amino-terminal fragment of apolipoprotein E4 leads to behavioral deficits, increased PHF-1 immunoreactivity, and mortality in zebrafish

2022-07-07

Abstract excerpt

Although the increased risk of developing sporadic Alzheimer’s disease (AD) associated with the inheritance of the apolipoprotein E4 ( APOE4 ) allele is well characterized, the molecular underpinnings of how ApoE4 imparts risk remains unknown. Enhanced proteolysis of the ApoE4 protein with a toxic-gain of function has been suggested and a 17 kDa amino-terminal ApoE4 fragment (nApoE4 1-151 ) has been identified i...

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Literature Corpus work: 505a4a75-5786-5f37-8ab6-543ac42f955b
DOI: 10.1101/2022.07.07.499128

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