Article
Discrete carboxyl-terminal segments of apolipoprotein E mediate lipoprotein association and protein oligomerization.
The Journal of biological chemistry - 25 Jul 1993
Westerlund J A, Weisgraber K H
Abstract excerpt
The carboxyl terminus of apolipoprotein (apo) E is required for lipoprotein association and for tetramer formation. To correlate these roles with specific regions within the carboxyl terminus, a series of apoE3 variants with carboxyl-terminal truncations at residues 266, 244, 223, and 191 were expressed in Escherichia coli. As determined by gel permeation and sedimentation equilibrium centrifugation, the four...
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