Inter- and intrafamilial heterogeneity: effective sampling strategies and comparison of analysis methods.

Article

Inter- and intrafamilial heterogeneity: effective sampling strategies and comparison of analysis methods.

American journal of human genetics - 1 Oct 1992

Durner M, Greenberg D A, Hodge S E

Abstract excerpt

Heterogeneity, both inter- and intrafamilial, represents a serious problem in linkage studies of common complex diseases. In this study we simulated different scenarios with families who phenotypically have identical diseases but who genotypically have two different forms of the disease (both for...

Topics

Computer Simulation
Family
Gene Frequency
Genetic Diseases, Inborn
Genotype
Humans
Models, Genetic
Models, Statistical
Pedigree
Phenotype
Sampling Studies

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