Phenocopies versus genetic heterogeneity: can we use phenocopy frequencies in linkage analysis to compensate for heterogeneity?

doi:10.1159/000154363

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Article

Phenocopies versus genetic heterogeneity: can we use phenocopy frequencies in linkage analysis to compensate for heterogeneity?

Human heredity - 1 Jan 2000

Durner M, Greenberg D A, Hodge S E

Abstract excerpt

In this study we explore whether a phenocopy frequency (defined as a "penetrance' for nondisease genotypes) can approximate or model genetic heterogeneity in a single-locus analysis. We simulated two types of heterogeneity situations: "sporadic models', where there are two forms of a disease, one...

Topics

Gene Frequency
Genetic Heterogeneity
Genetic Linkage
Humans
Lod Score
Models, Genetic
Phenotype

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