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Article

Effect of genetic heterogeneity and assortative mating on linkage analysis: a simulation study.

American journal of human genetics - 1 Nov 1997

Falk C T

Abstract excerpt

Linkage studies of complex genetic traits raise questions about the effects of genetic heterogeneity and assortative mating on linkage analysis. To further understand these problems, I have simulated and analyzed family data for a complex genetic disease in which disease phenotype is determined by two unlinked disease loci. Two models were studied, a two-locus threshold model and a two-locus heterogeneity model....

Topics

Computer Simulation
Female
Founder Effect
Genetic Diseases, Inborn
Genetic Heterogeneity
Genetic Linkage
Genetics, Population
Genotype
Humans
Lod Score
Male
Models, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pedigree

Phenotype

Recombination, Genetic

Sexual Behavior

Source

Open in PubMed Open full text

Identifiers

PMID: 9345086
DOI: 10.1086/301591
PMCID: PMC1716020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9345086-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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