Admixture effects in the traditional linkage analysis of admixed families.

Abstract excerpt

INTRODUCTION: Families of admixed ancestry are routinely excluded from traditional linkage analysis (LOD score) or are analyzed as deriving from a homogeneous population of the proband's ethnicity. Using traditional linkage analysis methods to analyze these families is complicated due to the admixture of different disease rates and allele frequencies that occurs. The presence of admixture violates the key...

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