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Article

APOE Variants in an Iberian Alzheimer Cohort Detected through an Optimized Sanger Sequencing Protocol.

Genes - 22 Dec 2020

González Ricardo D, Gomes Iva, Gomes Catarina, Rocha Rita, Durães Luís, Sousa Patrícia, Figueruelo Manuel, Rodríguez Maria, Pita Carmen, Hornero Roberto, Gómez Carlos, Lopes Alexandra M, Pinto Nádia, Martins Sandra

Abstract excerpt

The primary genetic risk factor for late onset Alzheimer's disease (LOAD) is the APOE4 allele of Apolipoprotein E (APOE) gene. The three most common variants of APOE are determined by single nucleotide polymorphisms (SNPs) rs429358 and rs7412. Our aim was to estimate allele and genotype frequencies of APOE variants in an Iberian cohort, thus helping to understand differences in APOE-related LOAD risk observed...

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Identifiers

PMID: 33375167
DOI: 10.3390/genes12010004
PMCID: PMC7822120

Genes

APOE
GC

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