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Article

Lack of association between the CYP46 gene polymorphism and Italian late-onset sporadic Alzheimer's disease.

Neurobiology of aging - 1 May 2006

Tedde Andrea, Rotondi Mario, Cellini Elena, Bagnoli Silvia, Muratore Laura, Nacmias Benedetta, Sorbi Sandro

Abstract excerpt

Recent studies have provided evidence toward the possible involvement of brain cholesterol homeostasis in late-onset Alzheimer's disease (LOAD). We analyzed an intronic T-->C substitution (rs 754203) of the cholesterol 24S-hydroxylase (CYP46) gene, encoding an enzyme acting on brain cholesterol turnover, which has been recently associated with an increased risk of AD, dependent or not on Apolipoprotein E (ApoE)...

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Identifiers

PMID: 16055229
DOI: 10.1016/j.neurobiolaging.2005.03.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lack of association between the CYP46 gene polymorphism and Italian late-onset sporadic Alzheimer's disease.PMID 16055229Read ↗

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