Article
A combination of closely associated positive and negative cis-acting promoter elements regulates transcription of the skeletal alpha-actin gene.
Molecular and cellular biology - 1 Feb 1990
Chow K L, Schwartz R J
Abstract excerpt
The chicken skeletal alpha-actin gene promoter region provides at least a 75-fold-greater transcriptional activity in muscle cells than in fibroblasts. The cis-acting sequences required for cell type-restricted expression within this 200-base-pair (bp) region were elucidated by chloramphenicol acetyltransferase assays of site-directed Bg/II linker-scanning mutations transiently transfected into primary cultures....
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