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Article

A combination of closely associated positive and negative cis-acting promoter elements regulates transcription of the skeletal alpha-actin gene.

Molecular and cellular biology - 1 Feb 1990

Chow K L, Schwartz R J

Abstract excerpt

The chicken skeletal alpha-actin gene promoter region provides at least a 75-fold-greater transcriptional activity in muscle cells than in fibroblasts. The cis-acting sequences required for cell type-restricted expression within this 200-base-pair (bp) region were elucidated by chloramphenicol acetyltransferase assays of site-directed Bg/II linker-scanning mutations transiently transfected into primary cultures....

Topics

Actins
Animals
Base Sequence
Chickens
Gene Expression Regulation
Genes
Genes, Regulator
Humans
Molecular Sequence Data
Muscles
Mutation
Plasmids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Restriction Mapping

Sequence Homology, Nucleic Acid

Transcription, Genetic

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 2300053
DOI: 10.1128/mcb.10.2.528-538.1990
PMCID: PMC360830

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2300053-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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