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Article

GATA elements control repression of cardiac troponin I promoter activity in skeletal muscle cells.

BMC molecular biology - 17 Sept 2007

Di Lisi Raffaella, Picard Anne, Ausoni Simonetta, Schiaffino Stefano

Abstract excerpt

BACKGROUND: We reported previously that the cardiac troponin I (cTnI) promoter drives cardiac-specific expression of reporter genes in cardiac muscle cells and in transgenic mice, and that disruption of GATA elements inactivates the cTnI promoter in cultured cardiomyocytes. We have now examined the role of cTnI promoter GATA elements in skeletal muscle cells. RESULTS: Mutation or deletion of GATA elements induces...

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Identifiers

PMID: 17875210
DOI: 10.1186/1471-2199-8-78
PMCID: PMC2045674

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