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Article

Segregated regulatory elements direct beta-myosin heavy chain expression in response to altered muscle activity.

The Journal of biological chemistry - 14 May 1999

McCarthy J J, Vyas D R, Tsika G L, Tsika R W

Abstract excerpt

Our previous transgenic analyses revealed that a 600-base pair beta-myosin heavy chain (betaMyHC) promoter conferred mechanical overload (MOV) and non-weight-bearing (NWB) responsiveness to a chloramphenicol acetyltransferase reporter gene. Whether the same DNA regulatory element(s) direct betaMyHC expression following MOV or NWB activity in vivo remains unknown. We now show that a 293-base pair betaMyHC promoter...

Topics

Animals
Blotting, Northern
Chromosome Mapping
DNA
Gene Expression Regulation
Genes, Regulator
Humans
Mice
Mice, Transgenic
Muscles
Myosin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Stress, Mechanical

Weight-Bearing

Source

Identifiers

PMID: 10318848
DOI: 10.1074/jbc.274.20.14270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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