Article
Transcription factor RTEF-1 mediates alpha1-adrenergic reactivation of the fetal gene program in cardiac myocytes.
Circulation research - 13 Jul 1998
Stewart A F, Suzow J, Kubota T, Ueyama T, Chen H H
Abstract excerpt
Alpha1-adrenergic receptor stimulation induces cardiac myocytes to hypertrophy and reactivates many fetal genes, including beta-myosin heavy chain (betaMyHC) and skeletal alpha-actin (SKA), by signaling through myocyte-specific CAT (M-CAT) cis elements, binding sites of the transcriptional enhanc...
Topics
- Actins
- Adrenergic alpha-Agonists
- Animals
- Animals, Newborn
- Bone and Bones
- Chloramphenicol O-Acetyltransferase
- DNA-Binding Proteins
- Fetus
- Gene Expression Regulation
- Muscle Proteins
- Mutation
- Myocardium
- Myosin Heavy Chains
- Nuclear Proteins
- Promoter Regions, Genetic
- Rats
- Receptors, Adrenergic, alpha
- TEA Domain Transcription Factors