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Article

Transcription factor RTEF-1 mediates alpha1-adrenergic reactivation of the fetal gene program in cardiac myocytes.

Circulation research - 13 Jul 1998

Stewart A F, Suzow J, Kubota T, Ueyama T, Chen H H

Abstract excerpt

Alpha1-adrenergic receptor stimulation induces cardiac myocytes to hypertrophy and reactivates many fetal genes, including beta-myosin heavy chain (betaMyHC) and skeletal alpha-actin (SKA), by signaling through myocyte-specific CAT (M-CAT) cis elements, binding sites of the transcriptional enhancer factor-1 (TEF-1) family of transcription factors. To examine functional differences between TEF-1 and related to...

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Source

Identifiers

PMID: 9670917
DOI: 10.1161/01.res.83.1.43

Genes

TEF
CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transcription factor RTEF-1 mediates alpha1-adrenergic reactivation of the fetal gene program in cardiac myocytes.PMID 9670917Read ↗

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A β<sub>1</sub>-adrenergic receptor CaM kinase II-dependent pathway mediates cardiac myocyte fetal gene inductionSemantic proximity Read ↗

Thyroid hormone receptor alpha 1: a switch to cardiac cell "metamorphosis"?Semantic proximity Read ↗

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M-CAT binding factor, a novel trans-acting factor governing muscle-specific transcription.Semantic proximity Read ↗

An in vivo analysis of transcriptional elements in the mouse alpha-myosin heavy chain gene promoter.Semantic proximity Read ↗

Reengineering Inducible Cardiac-Specific Transgenesis With an Attenuated Myosin Heavy Chain PromoterSemantic proximity Read ↗

Transcriptional Regulation of the Fetal Cardiac Gene ProgramSemantic proximity Read ↗

Muscle-enriched TEF-1 isoforms bind M-CAT elements from muscle-specific promoters and differentially activate transcription.Semantic proximity Read ↗

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