Article
The yellow mouse obesity syndrome and mechanisms of agouti-induced obesity.
Obesity research - 1 Sept 1999
Moussa N M, Claycombe K J
Abstract excerpt
The yellow mouse obesity syndrome is due to dominant mutations at the Agouti locus, which is characterized by obesity, hyperinsulinemia, insulin resistance, hyperglycemia, hyperleptinemia, increased linear growth, and yellow coat color. This syndrome is caused by ectopic expression of Agouti in multiple tissues. Mechanisms of Agouti action in obesity seem to involve, at least in part, competitive melanocortin...
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