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Article

GH-releasing peptide-2 increases fat mass in mice lacking NPY: indication for a crucial mediating role of hypothalamic agouti-related protein.

Endocrinology - 1 Feb 2002

Tschöp Matthias, Statnick Michael A, Suter Todd M, Heiman Mark L

Abstract excerpt

Ghrelin, an endogenous GH secretagogue, is capable of stimulating adiposity in rodents. Because such adiposity was thought to be mediated by hypothalamic NPY neurons, we investigated by which mechanism a synthetic ghrelin receptor agonist, GHRP-2, would generate a positive energy balance in NPY-deficient [Npy(-/-) mice] and wild-type controls. A dose-dependent increase in body weight and food intake was observed...

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Share to Absorptiometry, Photon
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Calorimetry, Indirect

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Share to Receptors, Corticotropin

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Source

Identifiers

PMID: 11796511
DOI: 10.1210/endo.143.2.8633

Genes

NPY
AGRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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