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Article

No evidence of a significant role for CTLA-4 in multiple sclerosis.

Journal of neuroimmunology - 1 Feb 2006

Roxburgh Richard H, Sawcer Stephen, Maranian Mel, Seaman Shaun, Hensiek Anke, Yeo Taiwai, Deans Jackie, Compston Alastair

Abstract excerpt

Variation in the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene plays a significant role in determining susceptibility to autoimmune thyroid disease and type 1 diabetes. Its role in multiple sclerosis is more controversial. In order to explore this logical candidate more thoroughly, we genotyped 771 multiple sclerosis trio families from the United Kingdom for the 3' untranslated region variable number...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16325273
DOI: 10.1016/j.jneuroim.2005.10.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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No evidence of a significant role for CTLA-4 in multiple sclerosis.PMID 16325273Read ↗

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Genomic regulation of CTLA4 and multiple sclerosis.Semantic proximity Read ↗

CTLA4 CT60 single-nucleotide polymorphism is associated with Slovenian inflammatory bowel disease patients and regulates expression of CTLA4 isoforms.Semantic proximity Read ↗

CT60 single nucleotide polymorphisms of the cytotoxic T-lymphocyte-associated antigen-4 gene region is associated with Graves' disease in an Italian population.Semantic proximity Read ↗

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