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Article

CTLA4 is associated with susceptibility to multiple sclerosis.

Journal of neuroimmunology - 1 Jan 2003

Kantarci Orhun H, Hebrink David D, Achenbach Sara J, Atkinson Elizabeth J, Waliszewska Alicja, Buckle Guy, McMurray Cynthia T, de Andrade Mariza, Hafler David A, Weinshenker Brian G

Abstract excerpt

We comprehensively screened CTLA4 for novel genetic variations in patients with MS. We studied genetic variations by association methods in a population-based sample of 122 sporadic patients with MS and 244 age-, gender- and ethnicity-matched controls, and by linkage and family-based association methods in 395 individuals from 59 American multiplex pedigrees with 141 affected individuals. Being homozygous for...

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Source

Identifiers

PMID: 12507781
DOI: 10.1016/s0165-5728(02)00395-8

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CTLA4 is associated with susceptibility to multiple sclerosis.PMID 12507781Read ↗

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Progression of multiple sclerosis is associated with exon 1 CTLA-4 gene polymorphism.Semantic proximity Read ↗

The role of non-HLA single nucleotide polymorphisms in multiple sclerosis susceptibility.Semantic proximity Read ↗

Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility.Semantic proximity Read ↗

No evidence to support CTLA-4 as a susceptibility gene in MS families: the Canadian Collaborative Study.Semantic proximity Read ↗

No evidence for association of CTLA-4 gene polymorphisms with the risk of developing multiple sclerosis: a meta-analysis.Semantic proximity Read ↗

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