Article
CT60 single nucleotide polymorphisms of the cytotoxic T-lymphocyte-associated antigen-4 gene region is associated with Graves' disease in an Italian population.
Thyroid : official journal of the American Thyroid Association - 1 Mar 2005
Petrone Antonio, Giorgi Gabriele, Galgani Andrea, Alemanno Irene, Corsello Salvatore M, Signore Alberto, Di Mario Umberto, Nisticò Lorenza, Cascino Isabella, Buzzetti Raffaella
Abstract excerpt
Graves' disease (GD) is an autoimmune and polygenic disorder. Several studies have shown that human leukocyte antigen (HLA) class II and the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene are involved in the genetic susceptibility. We performed a case control study on 150 patients with GD and 301 controls, matched for age and gender, to verify the association of three polymorphisms located in CTLA-4...
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