Article
Distribution of the CTLA-4 single nucleotide polymorphisms CT60G>A and +49A>G in psoriasis vulgaris patients and control individuals from a Polish Caucasian population.
International journal of immunogenetics - 1 Feb 2008
Łuszczek W, Majorczyk E, Nockowski P, Pluciński P, Jasek M, Nowak I, Wiśniewski A, Kuśnierczyk P
Abstract excerpt
Psoriasis vulgaris is a multifactorial disease with an autoimmune component, and T lymphocytes seem to be involved in its aetiology. CTLA-4 molecule is an important down-regulator of T-lymphocyte activation, and several polymorphisms of the CTLA-4 gene were found to be associated with some autoimmune diseases. We examined whether single nucleotide polymorphisms (SNPs) in the CTLA-4 gene, CT60A>G and +49A>G, are...
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