Article
CT60 genotype does not affect CTLA-4 isoform expression despite association to T1D and AITD in northern Sweden.
BMC medical genetics - 6 Feb 2007
Mayans Sofia, Lackovic Kurt, Nyholm Caroline, Lindgren Petter, Ruikka Karin, Eliasson Mats, Cilio Corrado M, Holmberg Dan
Abstract excerpt
BACKGROUND: Polymorphisms in and around the CTLA-4 gene have previously been associated to T1D and AITD in several populations. One such single nucleotide polymorphism (SNP), CT60, has been reported to affect the expression level ratio of the soluble (sCTLA-4) to full length CTLA-4 (flCTLA-4) iso...
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