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Article

Genomic regulation of CTLA4 and multiple sclerosis.

Journal of neuroimmunology - 15 Oct 2008

Palacios Ricardo, Comas David, Elorza Jorge, Villoslada Pablo

Abstract excerpt

The cytotoxic T lymphocyte antigen 4 gene (CTLA4) is a critical regulator of T-cell activation and it is an important therapeutic target for cancer and autoimmune diseases. Here, we analyzed the genomic regulation of CTLA4 gene expression in order to identify single nucleotide polymorphisms (SNPs) that affect its expression and splicing, and to assess their association with Multiple Sclerosis (MS). We analyzed...

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Topics

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Share to Antigens, CD
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Linkage Disequilibrium

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 18691768
DOI: 10.1016/j.jneuroim.2008.06.021

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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